I'm pretty sure it's a hard thing to run a online casino from within the US if that's what you're asking. Most gambling sites that I know operate from outside. It was also pretty dubious to use these sites from within the US but that situation may have changed recently, I don't know.
Forget running online casinos from the US, even allowing US customers to access your offshore casino can be problematic.
Satoshidice and Luckybit block IP addresses from the US from gambling on their sites.
https://www.cryptocoinsnews.com/bitcoin-gambling-site-satoshibet-turns-back-united-states-market/There seems to be a common misperception that US users of online gambling and poker sites are breaking the law. This is usually not the case. Except for in a few states, it's perfectly for us residents to use these and other gambling sites.