It is not like House always win. I've seen some aspiring new casinos gone bankrupt because couple lucky patrons killed casino's funds. Casino bankruptcy certainly can happen.
There are no casino that has been bankrupted yet if all players dont cheat the game. There are house edge to safe guard the casino so it wont fail in long term and will keep on generating profit. The only thing that you can do to make a casino bankrupt is either to steal (hack) or find some exploit to empty the bankroll
because casinos are businesses, plain and simple. they wouldnt stay in business if their business model or plan involved going bankrupt. whatever games casinos host on their sites, they are designed to profit the house more times than players will win. and even in a game where the house isnt even involved, such as in poker, the house still profits from taking a rake of every pot.