That's practically impossible. If they happen to do so, it won't take much time for the US government to chase them down, where after that we'll run into the same drama again. But even if they do end up returning, only a total idiot will make use of an exchange being operated by the same BTC-E staff.
You are so westernized in your thoughts, its really getting awkward. Impossible because the big mighty USA put a picture on a domain? Many countries and individuals give a shit about USA and only because USA says everything is illegal, it doesn't mean it is. If they open up again, I bet 90% of the Russians will use them again. Why USA is imposing sanctions against Russia and Russia isn't bending over?
This is not about the ways or styles of thinking
If we are to remain honest, we should accept the fact that the US is effectively controlling the monetary and, more broadly, financial flows around the world (at least, the better part of them). At a time, the train of events got close to cutting Russia itself from the SWIFT international payment system. Right now Russia tries to get itself out of these ties and break away with the payment systems controlled by Uncle Sam. In fact, it is not about using Btc-e again if (when) it restarts (most people will be happy to use it again anyway) but rather how useful it will ever be. As I see it, they could only restart (in any meaningful way) as a cryptocurrency only exchange with no fiat deposits and withdrawals (like Bitfinex had been cut off of the fiat transfer channels in April)