So, with bitcoin trading near $4300 now its return rate on investment (considering you bought it somewhere in 2010 for $0.01) equals 43 000 000 %. Whether it can be considered a bubble or not remains more of a philosophical question, but it is obvious that we will not observe the similar growth rate in bitcoin in the coming years. (Personally I think that bitcoin is way overpriced due to a sudden public and regulative interest, but it does not mean we cannot make money on it

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Which brings the question about other opportunities to get this kind of return. I suppose these opportunities should be yet unknown to general public like bitcoin was in 2010. You can think about altcoins/ICO's, but many altcoins are just copies of bitcoin in one way or another, their prices are highly correlated with bitcoin only with higher beta(more volatile), and a lot of people already know about them and invest in them, which limits their potential growth.
Considering ICO, personally, I am very pessimistic about them now. I think that the majority of current ICOs are merely scams, and because of all this ICO-hype you are very unlikely to determine the project which will become the next Google (if there is any at all). Anyway, the point is that even with ICOs you will hardly earn the equivalent return of bitcoin in 2010-2017 due to the market becoming more effective and regulated and as a result less volatile.
So in order to get this kind of excessive return we need to identify the next likely bubble, buy into it and wait until it becomes famous like the bitcoin. Do you think such instruments exist in blockchain world? Or you would bet on other tech sectors?