I have the same error since middle PM with metamask on ED...
Always a popup error message :
"You tried to send an Ethereum transaction but there was an error. Make sure you have enough ETH in your "Wallet" column to pay for the gas fee. If you already have a pending transaction (enter your address on Etherscan to find out), please wait for it to confirm, or increase your "gas price" (in the upper right dropdown) and try again."
I hope it's not kitties again

I didn't try with my ledger nano S (not yet configured, just received it yesterday). Anyone tried ?