First of all, you need to hold the cryptocurrency exclusively on the hardware wallet. I prefer firmware wallet Ledger. In the Ledger Blue version, up to 10 coins can be wounded at the same time.
The safenest depends on ways we will use it having trezor or ledger can definitely help. And in terms of exchanges and visiting sites just avoid to be phished and always find time to learn to study the every crypto. It's good to know more and be guided.
We need to use good and safe wallets trezor is good to use but sometime it does not appear to be safe the most, I think bitcoin is safe using bitcoin wallets like blockchain which has private key and password not good to share with anyone, hackers are around us who are in search of chance to scam with us dont open all kind of links to, people hacks by making some fake sites and names is as PROFIT MAKING s those are scammers they just attract people by such captions so dont open unknown links.