Anyhow, if you want to trade BTC -> Altcoins, i don't see why you would use anything other than Binance for popular altcoins.
For larger coins, yes. I've had some success buying lesser known coins on exchanges like Cryptopia, Kucoin and Mercatox and flipping them after they got listed on major exchanges like Binance.
I like Gemini for long term swing trading and holding/withdrawing USD. It feels a lot safer than most alternatives.