No BTC are known to be lost, even those which people claim to be lost could still one day be accessed so they cannot be removed from the supply. Those BTC still exist so they must be considered. So no, the graph should not be changed.
Actually there are nearly 10% lost, by different calculations. By small wallets like private holders losing their private keys for reasons like failed HDD and no backup to big fishes on different crypto-exchanges.
I voted for: yes, but the value can't be determined. Also, this loss doesn't have any influence on the current spot price.