Have you tried psychedelics? I can see MDMA leaving you indifferent depending on the circumstances, but with psychedelics I'd be hard pressed to believe that they wouldn't be profoundly notable even if they'd leave you fully functional on lower doses.
Nope. Never will.
I've known a few people who set off on a trip and never really came back. I don't think it should be as readily eulogised as it is by all and sundry after staring into a few pairs of eyes that were basically rendered empty by them.