If you're gonna be a pro trader and work with large amounts, then yes.
That would be an illogical decision. There is no hard and fast rule that a person with large amount of money should try margin trading. Rather its the opposite, because you would want to save your money from getting burnt if you care for it.
Definitely if you are big whale then this question does not arise, however for those who are hoping to monetize their own pump/dumped market manipulations should do so with a huge bag of money as backup in case things go wrong. This is not something that the average trader would be able to do so I stand against it generally.
I am also against margin trading especially in this market, it is as if the volatility of this market is not enough for people and they want even more risk, it is true we need the volatility in order to make money in whatever market we choose but when I see people margin trading I do not see them reducing their position size so their exposure to the market is smaller in case things go wrong and when they do, and they will if you keep trading, one single loss is enough to wipe their capital completely and then they try to blame the exchange for their lousy money management skills.