I don't think we can discount Man City... particularly if they get Kane, which is still a possibility.
Without Kane, I think Manchester City will still be considered one of the EPL teams that are on the list for the title every season. There is no doubt about the quality of the players even though yesterday they lost 1 goal to Tottenham. Kane may be able to give new energy to Manchester City's attack, but do you think he fits into Guardiola's tactics?