I will quote individual sentences or paragraphs, but I am responding to each section of your reply.
SARS-CoV-2 has non-human reservoirs and is now endemic. It will never go away. Period. It cannot be eradicated by vaccination, and anyone telling you it can be straight-up eradicated like smallpox with a high level of vaccination is lying. The current agenda of boosters will lead, inevitably, to bi-yearly shots, because the vaccine antibodies are waning within 6 months.
The vaccines can be modified to target the Delta variant. Billions of people get yearly flu shots, which are modified every year, without any adverse effects.
It has previously been suggested that antioxidants are useful for treating sepsis, because sepsis involves the over-activity of pro-oxidant enzymes that the body uses to fight infection.
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It is entirely possible that COVID-19 hyperinflammation is, much like Keshan disease, a disease of low antioxidant capacity (redox equilibrium issues in the body due to chronic oxidative stress, i.e., endothelial dysfunction) that can be counteracted by raising levels of antioxidant substrates, such as selenium, glutathione, et cetera.
This next section you have written includes a lot of speculation. Yes, we know COVID causes sepsis. Yes, we know that sepsis create a lot of reactive oxygen species and free radicals. So we speculate that treating with anti-oxidants would help. But every reputable large study (as I linked to in my previous post) we have on this issue has shown no benefit with antioxidant treatments.
Obviously I agree that people should stay fit and healthy, and if you want to take a vitamin C supplement, then knock yourself out. But we have no evidence that it (or other antioxidants) are an effective treatment for critically ill patients.
It's not conclusive proof of therapeutic effect, but it does point towards a fresh avenue of study.
This section is again more speculation, but at least you are acknowledging it. As and when human studies come out which say that these treatments are effective, then I will gladly consider using them, but I'm not going to randomly experiment on people on the basis of a study based on rodent gastric cells.
I said, in the letter, that it was a catch-22, because you need oxygen to live. Intubation does increase oxygenation, but also causes VILI-like damage and additional oxidative stress alongside that.
I'm not denying the cycle of NETosis, hypochlorous acid, and heme destruction. And I'm also not denying the existence of VALI/VILI, which is well described in the literature. But you also made the following two statements:
Make no mistake, intubation will kill people who have COVID-19.
Pumping O2 into the lungs does not make RBCs chemically incapable of carrying O2 somehow magically capable of carrying it.
Yes this cycle happens, but not to such a degree that there is no functioning hemoglobin and that intubation and ventilation will not save the life of a critically hypoxic patient. To claim otherwise is dangerously wrong.
Early and proactive use of antioxidants, steroids, and non-invasive ventilation would likely render intubation pointless.
We do this already. Everyone who comes through the door gets dexamethasone and remdesivir pretty much immediately. If they require HFNO or NIV they also get tocilizumab. Intubation is always a last resort. You can see national treatment guidelines here:
https://www.covid19treatmentguidelines.nih.gov/management/clinical-management/hospitalized-adults--therapeutic-management/
These studies virtually all enroll people who have COVID-19 hyperinflammation, have been symptomatic for around a week or more, and have been hospitalized.
The meta-analysis I linked in my previous post (
https://www.bmj.com/content/373/bmj.n949) examined ivermectin and hydroxychloroquine as both pre- and post-exposure prophylaxis, and found no evidence of efficacy for either drug.
I'm not entirely sure what points you are trying to make with your section regarding the vaccine (even ignoring your obvious conspiracy nonsense at the bottom). If you are worried about the vaccine producing the S1 subunits, then what do you think happens with an active COVID infection? If you are worried about the spike protein itself, then why would you not want to avoid the cascade of it you would get with a COVID infection, which is several orders of magnitude higher than what you would get with a vaccine? I mean, the quote that you shared even specifically says "post-infection of COVID-19 includes a myriad of neurologic symptoms including neurodegeneration". Why would you not want to avoid this by taking the vaccine?