Quote from: o_e_l_e_o on Today at 09:02:41 PM

The vaccines can be modified to target the Delta variant. Billions of people get yearly flu shots, which are modified every year, without any adverse effects.

That is true. But then again, SARS-CoV-2 is not the flu. It is an incredibly nasty betacoronavirus, every part of which is injurious to the human body, especially the Spike protein, which is responsible for many - but not all - of its pathogenic processes.

Quote from: o_e_l_e_o on Today at 09:02:41 PM

This next section you have written includes a lot of speculation. Yes, we know COVID causes sepsis. Yes, we know that sepsis create a lot of reactive oxygen species and free radicals. So we speculate that treating with anti-oxidants would help. But every reputable large study (as I linked to in my previous post) we have on this issue has shown no benefit with antioxidant treatments.

What I don't get is why we aren't seeing any results for many of these antioxidant trials.

https://clinicaltrials.gov/ct2/show/NCT04570254

https://clinicaltrials.gov/ct2/show/NCT04323228

https://www.clinicaltrials.gov/ct2/show/NCT04377789

https://clinicaltrials.gov/ct2/show/NCT04880109

No data posted on the outcomes at all. APX-115 was pushed as a potential treatment early on, but then, we heard nothing.

https://us.acrofan.com/detail.php?number=266790

NAC seemed promising early on, but then, they stopped pursuing it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649937/

This study showed a benefit for oral antioxidant use:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160844/

There are papers that unironically suggest using curcumin - that is, turmeric pills - as Nrf2 antioxidant pathway activators to improve endogenous antioxidant activity.

https://www.frontiersin.org/articles/10.3389/fphar.2021.669362/full

https://pubmed.ncbi.nlm.nih.gov/33099890/

https://pubmed.ncbi.nlm.nih.gov/33352565/

Some studies have suggested, I kid you not, beet juice. I recommend reading this one from start to finish, since it echoes many of the concerns I've had:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340570/

Quote from: o_e_l_e_o on Today at 09:02:41 PM

Obviously I agree that people should stay fit and healthy, and if you want to take a vitamin C supplement, then knock yourself out. But we have no evidence that it (or other antioxidants) are an effective treatment for critically ill patients.

Micronutrient deficiency is endemic throughout the developed world. Given that 40% of Americans are Vitamin D deficient, some critically so (this gets worse the darker your skin is, with as many as 60% of Hispanics and 80% of African-Americans being Vitamin D deficient), there's no way that one Vitamin D pill a day could hurt. It could only help. Vitamin D helps lower anxiety, too.

https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.1760

Personally, I recommend raising one's levels of Vitamins A, B, C, D, E, and dietary nitrate, and taking NAC, selenium, quercetin, resveratrol, and curcumin, but avoiding hypervitaminosis, which can cause fatigue. The best and most bioavailable sources of vitamins are foodstuffs, not pills.

The best thing for one's blood vessels is to just eat a damn salad instead of hyper-processed, hyper-palatable crap loaded with sugar. Fish for Vitamin D, kale, beets, celery, cabbage, spinach, and kimchi for dietary nitrate, brazil nuts for selenium, garlic for cysteine, and maybe some turmeric-spiced chicken.

Not everything has to be a depressing pill. We'd all be a lot better off if we made the personal choice to take the colorful snack food boxes filled with pressed, baked grains dusted with salt and paprika and throw them in the trash and start eating real food and exercising right. People would be living longer, healthier lives. 1,200,000+ people died of cancer and heart disease last year in the US, many of them preventable cases, but you don't hear about that in the news, do you?

Quote from: o_e_l_e_o on Today at 09:02:41 PM

I'm not denying the cycle of NETosis, hypochlorous acid, and heme destruction. And I'm also not denying the existence of VALI/VILI, which is well described in the literature. But you also made the following two statements:

Quote

Make no mistake, intubation will kill people who have COVID-19.

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Pumping O2 into the lungs does not make RBCs chemically incapable of carrying O2 somehow magically capable of carrying it.

Yes this cycle happens, but not to such a degree that there is no functioning hemoglobin and that intubation and ventilation will not save the life of a critically hypoxic patient. To claim otherwise is dangerously wrong.

88% of the people intubated in New York died.

https://www.webmd.com/lung/news/20200422/most-covid-19-patients-placed-on-ventilators-died-new-york-study-shows#1

During that outbreak, Dr. Cameron Kyle-Sidell vocally expressed concerns that they were using the wrong treatment.

https://z3news.com/w/dr-cameron-kylesidell-treating-wrong-disease-change/

Another study shows that 45% of patients intubated are dying.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781141/

Granted, this is an intervention that is mostly reserved for critical cases that would otherwise have a fatal outcome. I recognize that. However, there has to be some manner of adjunct therapy that can protect the tissues from damage. Suctioning these people, having tons of blood and goo come out of them periodically, and then going right back to pumping air into their abused lungs, that cannot be good for lung physiology.

COVID-19 is an endotheliitis. It inflames small capillaries in the pulmonary alveoli and makes them more vulnerable to mechanical stretching. Also, at the same time, it causes coagulopathy, because endothelial cells are sloughing off and exposing the basement membrane and there's a lot of release of clotting factors due to all the inflammation. So, when they start pumping these people up with blood thinners, they're balancing anticoagulation with hemorrhage. I heard of one rather horrific case of a teenage hispanic male in NY who died of intestinal hemorrhage because they kept pumping him up with heparin, but when they stopped heparin, he started clotting up again. Yes, that's a thing that actually happens with this virus.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446989/

I don't deny that COVID-19 is real, or that it can be deadly. A lot of people who are against the vaccine don't even think COVID-19 is real at all. They think it's a rebranded flu, or that it has never been isolated and sequenced, or that people with heart attacks and strokes are being relabeled COVID-19 deaths, without realizing that this virus can unironically cause people's D-dimer to shoot up to 20,000 ng/ml and turn their blood into syrup, especially if they're old or have had prior clotting disorders.

None of these papers describe a flu. What they describe is something maddening in its complexity and multifarious in its manifestations.

What frustrates me is the lack of mainstream media coverage of the deeper complexities of COVID-19's pathology. They haven't cleared anything up at all. There are articles here and there that give an accurate enough picture, but they're easily missed. Every talking head is still presenting COVID-19 as an airborne pneumonia and not an airborne blood vessel disease, almost two years into this.

Quote from: o_e_l_e_o on Today at 09:02:41 PM

We do this already. Everyone who comes through the door gets dexamethasone and remdesivir pretty much immediately. If they require HFNO or NIV they also get tocilizumab. Intubation is always a last resort. You can see national treatment guidelines here:

Why do I keep hearing about symptomatic people being sent home, and then coming back in severe or critical condition, then?

A good friend of mine died on one of those ventilators. I hadn't seen him in a few years and I was hoping to meet up with him. This is kind of personal for me, and I may have gotten a little heated up.

Quote from: o_e_l_e_o on Today at 09:02:41 PM

The meta-analysis I linked in my previous post (https://www.bmj.com/content/373/bmj.n949) examined ivermectin and hydroxychloroquine as both pre- and post-exposure prophylaxis, and found no evidence of efficacy for either drug.

Why do I keep seeing studies showing a benefit, then?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886121/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417612/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405705/

https://pubmed.ncbi.nlm.nih.gov/34375047/

Quote from: o_e_l_e_o on Today at 09:02:41 PM

I'm not entirely sure what points you are trying to make with your section regarding the vaccine (even ignoring your obvious conspiracy nonsense at the bottom). If you are worried about the vaccine producing the S1 subunits, then what do you think happens with an active COVID infection? If you are worried about the spike protein itself, then why would you not want to avoid the cascade of it you would get with a COVID infection, which is several orders of magnitude higher than what you would get with a vaccine? I mean, the quote that you shared even specifically says "post-infection of COVID-19 includes a myriad of neurologic symptoms including neurodegeneration". Why would you not want to avoid this by taking the vaccine?

Yes. You are correct. The protein is also harmful when the virus produces it in the body, and a lot of people who recovered from seemingly mild cases of COVID-19 may go on to have premature neurodegenerative disease as part of the nasty, SARS-like sequelae it inflicts. But try telling people that.

There was something that, as yet, I have not mentioned in my letter, but will likely make it into the next draft. There has been a reliable antidote to all of this, all along. One that doesn't involve having mRNA that codes for SARS-CoV-2 Spike, a pathogenic protein, injected into the body. It's called DRACO and it was funded by DARPA about a decade ago. They were looking for a means of inoculating soldiers against pandemic bioweapons. Any bioweapon. Even one that had never been seen before. An antivirus so effective, it may as well be called a universal vaccine.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022572

https://www.youtube.com/watch?v=PO6I00ZQcMI

DRACO, or Double-Stranded RNA Activated Caspase Oligomerizer, is a recombinant fusion protein that consists of a protein with a domain that hunts for viral double-stranded RNA bound end-to-end with a protein with an apoptosis-inducing domain, with HIV TAT added to allow it to slip right in past cell membranes. When injected into a living creature, the DRACOs enter basically all of their cells. If the protein detects no viral dsRNA in a cell, it does nothing and is non-toxic. If it encounters some, multiple DRACOs start binding to it, and then procaspases bind and crosslink on their exposed ends.

It's basically a little protein limpet mine that forces all infected cells in the body to self-destruct. It's non-toxic to healthy cells and persists in the body for about a week.

After DARPA funded the project for a while, the inventor demonstrated that it worked very well in mice (see that paper above), but then, all the funding dried up. Poof. Dr. Rider's Templeton Foundation grant fell through in a reorganization, and he resorted to basically begging for money on Indiegogo. An absolutely bizarre end for a concept that showed efficacy both in vitro in cell cultures, and in vivo in lab mice, and which was hailed as a discovery as important as Penicillin in popsci mags around ten years ago.

What do you wanna bet the Human Cattle Ranchers kept the real cure for themselves, and left us all to die?