Coins that are on the top 100 did not land there for anything they have investors' support and they have proven their worth in the market, if you have a new coin that is struggling to move because of lack of volume and lack of development you have to think twice and move to another coin, some coins are not worth holding on, you can be patient but there should be a limit on how patient you are on your investment.
A lot of depends how useful is the project and how it is popular and in demand. Now NFT very popular but and different NFT collections appear. For example
https://twitter.com/Buakaw113/status/1517463376066396160 which offers NFT from the fighting ring to the digital world.