Go and check Manchester United States against Spanish sides they usually find it very difficult to play against Spanish sides to Cadiz and to Real Sociedad in th group stage they didn't get things easier as they think.
The improvement so far seems like Manchester United and Barcelona might result to many goals. Dembele Injured is a big blow, Xavi will miss him amongst the current players he played a pivotal role when Lewandoski was booked for three game ban
What you were saying was true. MU has very bad record against Barcelona. MU was so difficult to beat Barcelona. Xavi has raphinha as a replacement for dembele. Raphinha has proven itself during the match against real betis. I think that there should not be a problem with barcelone even playing without dembele. Barcelona is feeling so good with the composition of the current squad. I think that this gonna be a game that may not able to be won by united. It's still a match that can't be determined easily
One thing with Manchester United as you said is no matter the kind of form they are, they always appear little in the eyes of Spanish clubs. Starting from their big clubs to Sevilla. I dont understand how it happens and why it happens. But this time 10 may be ready to change the narrative especially since he will play the match and it is a home and away meeting.
I think eras have changed and in this era of Erik ten Hag I'm sure Manchester United will be able to play well, even though Barcelona might eventually win but this match will still be interesting to look forward to. Also, regarding the players or squad that Barcelona have, basically they already have players who have good quality, so even if one key player is injured and or cannot be played, of course Xavi will be able to use other strategies by adjusting the available players.
So yes, this match will of course still be interesting but one thing I still believe in, it looks like Erik ten Hag will be able to make the right strategy in this match to make Manchester United qualify for the next round.