According to some speculation, Inter will play Dzeko over Lukaku at the start.
Not sure if it is the correct choice, for sure he has more experience.
Inzaghi was making this decission the whole season, and it has worked, so lets see, Lukaku against tired defenders can be much more decisive, the main them its , are gonna be tired the defenders if Inter doesnt attack?
If Inter doesn't attack, then of course Manchester City's defensive line will logically not be too tired, but in this way Manchester City will have many ways to create attacks. So yes, I think it doesn't matter whether Dzeko or Lukaku will be played first because after all, the most important thing is whether Inter can break Manchester City's dominance in the match later. Because, if Inter can't do a lot of attacks too, then Inter's forward players will at least help the defense a lot too right.
Whatever it is, I hope Inter knows that Manchester City is not going to be afraid of attacking a lot in this match. In fact, Manchester City is going to attack regardless of what the score is. So even if Inter somehow gets ahead in this match I don't believe there will be able to win the match by just defending and staying back. Because that is going to give Manchester City more chances to attack. Inter will have to take the attack on Manchester City.
I also believe that Inter will get a lot of Contra attacking chances because of Manchester United being aggressive in this match. Inter will have to convert those chances into goals. Otherwise interval probably not be able to win.