If Inter doesn't attack, then of course Manchester City's defensive line will logically not be too tired, but in this way Manchester City will have many ways to create attacks. So yes, I think it doesn't matter whether Dzeko or Lukaku will be played first because after all, the most important thing is whether Inter can break Manchester City's dominance in the match later. Because, if Inter can't do a lot of attacks too, then Inter's forward players will at least help the defense a lot too right.
I don't think Inter will have a chance to beat City's dominance in midfield. The most reasonable solution is to play the bus with the hope of counterattacks. If you block all the zones before your own penalty area, then despite the overwhelming possession of the ball, City will have few chances - it worked with Barcelona (that Barcelona of the tiki-taka times) and can work with City. In open football, Inter has no chance.