Playing at home will not guarantee that Sevilla can beat Real Madrid and maybe Sevilla must be prepared to accept the fact that Real Madrid has been impressive so far. In terms of squad depth, it is clear that there is a huge difference and Real Madrid seems to have no gaps that could allow them to lose.
I also have that view for Real Madrid if the opponent is Sevilla, because everyone has seen how these two teams have performed in the several matches they have played this season. So it is quite clear that Real Madrid has the possibility of getting full points at home to Sevilla in this week's match, besides that the match with Sevilla is an opportunity for Real Madrid to gain points distance from rivals such as Girona and Barcelona.
Currently there is a difference in quality between the two main teams, Real Madrid who are in their best performance and Sevilla who have not yet found their best performance, so it is clear that Real Madrid will be very favorites in this match.
Even though the match will be played at Sevilla, I don't think it will have a big impact on Real Madrid being able to win.
Now Real Madrid is at the top of the standings, and their performance is very good, of course they will make great efforts to maintain their good performance and also keep points away from their rivals in the La Liga standings.