Inter Milan, a strong team in the Italian Serie A league has for themselves so much work to do regarding keeping themselves in the title race both league wise and tournament wise, the Italian league has some competitions in it and Inter Milan has to level up to these tasks, as well as level up to the task in the Champions league where there are even bigger competitors,
player rotation is welcomed as just single set of players can't do it all for a team.
A balance needs to be found, you can't overwork a player and expect positive outcome from every game, they're not robots, they need some sort of rest in between or else they'll be destabilized, they are a team envisioning the UCL title and they've actually got what it takes but they just have to put in extra work and effort.
If the coach does not have many choices for the players he has then it will be difficult for him to rotate because play in players who are not ready will make the strategy not work well during the match. Moreover, if several key players are injured, this could affect the results of the match because Inter Milan is taking part in a different competition and the match schedule will definitely be even busier. Inter Milan's task is tough this season, apart from having to fight to get the Scudetto title, they also have the ambition to win the Champions League because last season they were runners-up.
Simeone Inzaghi will try to give his best for the team and he will also try to make several steps forward so that Inter Milan does not fail in Serie A. It takes calm and intelligence for him to choose several players when he has to rotate. The next match will be at Juventus headquarters and this will be a tough match for him because defeat could bring Inter Milan down to second place in the standings.