Even without Höjlund, Manchester United will win this match. I mean, if they want to be in the top four, they have to win. In recent games, even if they concede goals, they score a lot of goals and win. That's why defensive mistakes are not a big problem.
Hojlund's injury might affect Man United's performance. As we know, Hojlund has had quite an impressive performance recently and his instinct for scoring goals become sharp. So when Man United have to play without Hojlund it could be quite a tough battle for them. Man United does not have many options on the front line, so practically they will only rely on Rashford alone.
Losing Hojlund should not be a burden for Manchester United to end this match with a win, Manchester United needs to maintain its sharpness even without Hojlund in order to improve its position in the standings. The match has still been running for 33 minutes, the score has not changed for both teams. Manchester United must take advantage of this match in order to get full points. Manchester United players must increase their motivation when playing at Old Trafford to open their way into the top four.