Man City's chances are still great, the match against Arsenal could be key. If they win of course Man City will be ahead of the points, then it's a tough task to keep maintaining by continuing to get points in the remaining matches. But if the final result later draws or loses, then Man City will be more difficult, because they only hope for Arsenal and Liverpool's mistakes in the rest of the next match. De Bruyne's injury does not seem to be a big problem for Pep, they have to maximize the existing players.
The match between Manchester City and Arsenal is a very crucial match for both teams, so far we can see how the three compete very fiercely in the Premier League, but I think the journey of the three teams after next week's match is no less difficult because all three will still be faced with the remaining difficult matches, in the bigmatch next week of course Manchester City is the most favored team even though news circulates if some Their main player has an injury at this time.
The injuries to De Bruyne, Ederson and Walker will certainly not reduce Manchester City's performance in my opinion, indeed all three are important players in the current squad but we also cannot deny if Manchester City still have Ortega, Kovacic and some defenders who can replace Walker well, at the moment I think the game against Arsenal will be the toughest game besides Tottenham in their remaining games this season, In addition, I don't see there is another team that might be a strong opponent for Manchester City in the remaining of their matches this season.