The injuries to De Bruyne, Ederson and Walker will certainly not reduce Manchester City's performance in my opinion, indeed all three are important players in the current squad but we also cannot deny if Manchester City still have Ortega, Kovacic and some defenders who can replace Walker well, at the moment I think the game against Arsenal will be the toughest game besides Tottenham in their remaining games this season, In addition, I don't see there is another team that might be a strong opponent for Manchester City in the remaining of their matches this season.
I have a feeling all three will play against Arsenal. Man City have a history of players pulling out of internationals, to then miraculously recover for their club shortly after.
Arsenal are doing the same though, Saka pulled out of England camp and Gabriel is supposedly not fit to play for Brazil. Let’s see if they are all really injured at the weekend.