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There is no information about De Bruyne yet, let's hope that the injury is not so serious. It became known that Walker will be able to play against Arsenal, the injury was not serious, this is good, but with Ederson everything is not so good, according to preliminary forecasts he will be able to return to the game in mid-April, so he will most likely miss the games with Arsenal and Aston Villa, and also possibly the first game with Real Madrid in CL.
To be honest, I didn't realize that several of Manchester City's main players had recently been injured, so if that were true then of course Arsenal's chances of winning would be even greater. Manchester City doesn't feel special without De Bruyne in their squad, and neither does Ederson. These two players are needed in the Manchester City squad because of their influence, but if they are absent due to injury, of course Manchester City will have to work extra hard later.
I know Manchester City still holds the advantage because they are playing at home, but without De Bruyne's presence the team's performance is difficult to expect. Pep Guardiola will have to be extra careful when hosting Arsenal at the Etihad and he may need to consider the worst consequences of being without his two best pillars in the main line-up.
The fear that all coaches have when releasing key players to strengthen their respective countries is injury, Peg Guardiola and Arteta are feeling this right now. We hope that the City versus Arsenal match will be fierce, and both teams can field their best lineups. Undoubtedly, losing key players is a big loss for the team, the two coaches certainly have to find a solution to their absence from matches.
Walker, De Bruyne, Stones, Ederson are key players in City main squad, Pep Guardiola will certainly be confused if he cannot play them in the match against Arsenal. Meanwhile, Arteta himself is also facing the same situation, where three of his players Jurrien Timber, Gabriel Martinelli, and Saka are also reportedly injured. However, I am sure that the match will still be fierce, even though both teams will play a little cautiously.
On the other hand, City is lucky because they act as hosts, this will be an opportunity for revenge for their defeat in the first half of the season. Arsenal, who is currently in an impressive trend, will of course fight tooth and nail to maintain their secure position at the top of the standings. Even though victory tends to favor City, in my opinion Arsenal also have a chance to create a surprise.