I will try something and bet on the opposite of bookmakers favor in two of these matchups. One will be West Ham and the other one will be Roma.
Milan - Roma should already be considered as a really close matchup though. Unlike the gap between their championship odds I see them having near equal chance. Roma are much better as you have also mentioned. Milan are a really challenging opponent for them here maybe but this time they have a bigger chance with De Rossi.
Leverkusen are of course quite the favourite against West Ham on paper. However seeing them having big difficulties against Qarabag for some reason tells me to give West Ham a chance with a small bet. I'm doing this just for fun so let's see what happens.
Milan - Roma should already be considered as a really close matchup though. Unlike the gap between their championship odds I see them having near equal chance. Roma are much better as you have also mentioned. Milan are a really challenging opponent for them here maybe but this time they have a bigger chance with De Rossi.
Leverkusen are of course quite the favourite against West Ham on paper. However seeing them having big difficulties against Qarabag for some reason tells me to give West Ham a chance with a small bet. I'm doing this just for fun so let's see what happens.
I think in the Milan and Roma game, it is clear that Milan will be the favourites in that game, and of course I can see how Milan have performed in the league so far which has been quite consistent, indeed Roma is not an easy team to beat especially since the era of de Rossi coaching, but I think it is too risky to bet your money on their victory in that game, I don't mean to belittle Roma but I don't see if Roma have anything that can indeed be favored in the game against Milan except maybe Pioli who is a little blind to De Rossi's strategy, other than that of course Milan will be able to beat Roma like they did in the previous two games in the league.
Leverkusen is the favorite in the game, but Westham is also not a team that will be easy to beat, especially so far Westham has also performed quite impressive in the league, in addition to the lack of statistics and head to head of the two teams so far the official league, of course, it is difficult for us to predict who the team will win in the game, but even so the betting market installs Leverkusen as the favorite to win.
What you do in my opinion is quite reasonable, because it is really Supposed that we should go against the flow by Placing Bets on the not favorite team, because indeed in football all Possibilities can happen, besides that with small Bets but do not rule out the possibility that we can win bigger.