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Manchester city as a team are very good and I know for sure that they don't rely on a single player before they perform their magic and that's why I feel even if debryune is going to be absent they can still manage their way out of the game and maneuver their way to victory against arsenal although the winning is extremely needed by the two teams so I don't know how the outcome of the game will be till they have played it out.
I have said, Manchester City will not depend on one player and their victory or defeat will not depend on one player either.
They have Bernardo Silva, Phil Foden, Jack Grealish, Jeremy Doku, Kovacic, Nunes as midfielders, while Erling Haaland is also ready for the match. Pep Guardiola doesn't have many shortcomings even without De Bruyne and Ederson, but if those two players are there then of course Pep Guardiola has many complete options in his squad.
Arsenal are not favorites, but they have a chance. Everyone also knows that Manchester City is the favorite, but considering that Arsenal has big ambitions to maintain the top position in the standings, the match will be very high-tension.
Even though Pep Guardiola and Arteta do not have a complete squad, the match will take place at high intensity and we will witness an entertaining match. Pep Guardiola has no shortage of rotation options, he has quality players to fill his strat XI, as does Arteta, who this season has built a better squad depth than last season.
All the players in City main lineup are star players, Halaand tends to stand out more because of his role as the main goal scorer. However, we have seen that almost all City players can score goals at important moments, with Foden sometimes appearing more impressive than Halaand. Losing De Bruyne is indeed a big loss, meaning Arsenal can use it as an opportunity.
On the other hand, I think City will play more aggressively, because they have a grudge to settle and they want a place at the top of the standings. The strength of Arteta fleet will be tested, with most people still thinking they will not be able to handle the heavy pressure. In the Champions League, Arsenal were able to break any worries by advancing to the quarter finals, and we'll see if they can do it in the EPL, where City are the favorites.