These are actually different leagues.
But the biggest threat to the City is justice

A decision on their cheating will be made in 2025, hopefully before the end of the season.
The charges against Manchester City have gone on for quite a long time but with the current situation I'm not sure they will receive a severe punishment even if they are found guilty and they could even get away with a lot of charges at the moment

It can't be denied that Manchester City is a big club and the advantage the EPL has when Manchester City is in the competition is obviously huge so in this case I honestly doubt the charges will end with a tragic end for Manchester City just like some other clubs last season like Everton or Nottingham Forrest.
On the other hand for betting it seems reasonable especially for next season clubs like Liverpool, Chelsea and maybe even Manchester United will experience a transition with a new coach so it will be difficult to predict their performance will be immediately good with a new coach at the start of the season.