I don't think PSV will be able to win Juventus. Even though Juventus form this season has been not been so good, they have dropped points in matches that they should have won, I think their overall squad depth and experience in European competitions give them an edge over PSV. I doubt PSV have the technical ability or experience needed to eliminate Juventus.
Defeating Juventus will not be an easy job for PSV because if we compare the depth of the squad of both teams, of course Juventus is superior and in terms of their experience in this competition there is no doubt, but not easy does not mean impossible, if PSV uses the right strategy in the first leg when visiting Juventus' headquarters then in the 2nd leg PSV will be more confident.
Let's see what both teams will do in this crucial match, if PSV can really destroy Juventus I think Motta's career will be threatened.
Winning against Juventus is a big challenge for any team. Because this team plays very badly defensively. Juventus' defense is very difficult to break.
However, Juventus' performance in the last 5 matches of the Champions League is quite weak. Juventus drew in three matches. And in the last match they lost against Benfica. Also, a few days ago, Juventus faced their first defeat in Serie A. Juventus lost against Napoli. It is very difficult for PSV to beat Juventus, but it is not impossible. If PSV can play well, they have a chance to win. Especially the players in the attack of PSV must play well. Otherwise, it is not possible to break Juventus' strong defense.