I think it will be a match week where all three teams will win. Of course, Real Madrid will have a very difficult match because they have to rest their players for the Arsenal match. If they do not rest their players, they will not be able to find that little hope in the Arsenal match. If they do not take the field with their main squad, there is also the risk of losing points. Of course, Real has a very good squad, but small teams can always be challenging.
Real Madrid have high risk of losing point in La Liga this week and with already 4 points less than Barcelona now, if Real Madrid lose points and Barcelona win, La Liga title race will have a big twist when it has only 7 more match days after this week. With distraction from UEFA Champions League, Real Madrid will be not too ready for this week match in La Liga, and there is chance of dropping points.
The confidence that Barceclona has apart from the fact that they have gained a good mentality due to their improved performance, this is also suspected by several clubs in domestic competitions, especially Madrid, who are starting to experience a decline so that it is increasingly carried over in other competitions because they are now quite comfortable with their position so that they can be more able to focus on the other competitions they live too.
Barcelona improved their performances with the return of Lamine Yamal and since then they have played like unstoppable team. With this excellent form, they got a first position in La Liga back and went straightly in Champions League as well. Atletico Madrid don't have good chance in the title race, and only Real Madrid left for this race with Barcelona. Real Madrid are in two most important weeks this season, they must maintain difference with Barcelona in La Liga, but still have to prepare as best as possible for a second leg quarter final with Arsenal. After a big defeat in a first leg, Real Madrid will host Arsenal with a very huge task to win with at least three goal difference. It can affect their preparation for La Liga match this week and can cost them La Liga title if Barcelona win and expand difference bigger.