Some times, it's greed that makes some people not to accept cash out, they could think they are being smart by holding unto the game until they lose everything when the game bust. I have learned so much harsh lessons from losses that I deviced a strategy of staking on parlays and ever since I started using the strategy, I don't give chance to winning opportunities. It's either I accept one cash out on the first slip and allow the second slip to play out.
It's not a matter of strategy, but when it's worth withdrawing your winnings, I think it will depend on what your deposit is, if it's frankly small, then you shouldn't withdraw before you make x2, and if it's big enough, then you can set yourself the levels you'll reach when you withdraw, for example, you withdraw when you reach $100 (or more) in winnings, or $50, it's not that important, the most important thing is that there is such a tendency and compliance with this rule.
Withdrawals will be definitely be basing up into your own interest or decisions on when you would be gonna taking out the profits you are making. Cashing out will be that up to you but if you are that wanting to spend up those profits for playing that particular session then its not bad as long you arent that compromising your finances then it should be just that fine. So its up to you on how you do deal up with things because usually gamblers do end up miserable just because of ending up on having no control with their finances because on the time that you do lapse with those spending then this is where issues do start out.
Cash out when you do feel that you are contented with the profits that you are making but if you are just that going for the sake of fun then it will be that up to you.
Usually gamblers doesnt really that getting contented so easily and wanted up to play even further just because they do want to have more money or make winnings.