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There is no method that is 100% safe. However, if you know what you are doing and you do most things right, there is no need to be too paranoid.
I think it never hurts to be "too paranoid"! lol. Backups of backups of backups. Multisig etc. Particularly if you have something you don't want to lose.
It isn't like the bank or credit card where you can get help from anyone.