I will always say it that once you have something huge tangible beyond your wager then just cash it out. The cashing out feature is two sided though but the casino will always payout anyways just that they benefit more if the game later comes in for you. Nevertheless , if you hit a huge win with the cash-out open, don’t think twice just do it

..part of the win can be used to win multiple bets than just losing it at the end
My principle is that, once my cash out balance move up to 50% or above, I will go ahead to cash it out, I am not so interested in the total winning amount, since it's not mind until the final whistle is blown, unlike some who get so greedy with their bet, their already fix their minds on their potential winnings and this affects them when making decisions.