As far as I know no one has been able to easily compile and get this to run on OS X natively. However, you can run the miner (unfortunately without ufasoft's sse2 optimizations) using the following steps:
Urm. Have you tried to compile it natively using XCode on OSX 10.6 on a machine that can handle SSE2? I'd like to see some bug reports as to why it won't compile. I don't think there's anything super specific that would prevent a build from happening. I've seen nothing on what sort of compile errors one gets on OSX. Also remember, I crafted the SSE2 code in jgarzik's miner to require the 64-bit mode of Intel/AMD chips. So if you're running a 32-bit kernel/userspace, you won't be able to use it.
(I'd try myself, but my Mac is in little bits...and it's just a CoreDuo, so I couldn't test the SSE2 code if I wanted to)
I do know my SSE2 WILL NOT WORK in win64, since the calling ABI is different.
The one place where there probably is a problem is I used ELF64 as the output for yasm. That should be Mach-O for OSX...but it may also just work.