As long as you have the proper power supply connections (you should) and a motherboard with 2+ PCI Express slots (which yours has), the hardware angle will be simple - plug both cards in, attach auxiliary power, turn on pc!
Every OS I know of should be perfectly fine with this configuration.
Thx mate, asking because I've never done this before, I'm crossfiring my card actually but this case is not the same haha =D
@Mahkul : I've been mining for 2 weeks, so I know how to deal with software side, just did not know how to deal with hardware side ^^ , I'm using win 7 64 bit mate.
I only asked, because I got fed up trying to get two GPUs working on Windows XP and switched to Ubuntu. I am not saying it is impossible on Windows (some people got it working), but I ran into problems myself. I have no experience with it on Windows 7, so you probably will be fine.