I don't hold lots of bitcoin; there are people who own thousands of bitcoin. What if they die suddenly without sharing anyone about their wealth? We have lost lots of bitcoin already from the circulation but after a decade or two, I guess the number of lost bitcoin will be huge. The supply of bitcoin is limited by nature. With the lost bitcoin, it's getting more scarce. At some point, after few decades, the supply will huge limited.
My theory is that the rate of bitcoins lost is inversely related to the price. As they've become increasingly valuable, security has become of the utmost importance. Hardware wallets are the norm for new users. Institutions only want to work with qualified custodians with battled-tested cold storage.
I also think we are entering an era where bequeathing bitcoins will become commonplace, both through trusted legal channels and privately.
What effect do you think will it have on bitcoin? Certainly, you may think that price will be higher. Well, it will certainly but will it anymore be usable? With very much limited supply, won't it create disruption? Or, it will be as precious as diamond; I mean very much rare.
It's still a donation to the rest of us in an economic sense. In terms of
network effect, I would anticipate a much larger network in the future regardless -- it doesn't matter the number of coins that are lost.
Future adopters just won't own as many bitcoins as early adopters. That much is already obvious.