The injuries to De Bruyne, Ederson and Walker will certainly not reduce Manchester City's performance in my opinion, indeed all three are important players in the current squad but we also cannot deny if Manchester City still have Ortega, Kovacic and some defenders who can replace Walker well, at the moment I think the game against Arsenal will be the toughest game besides Tottenham in their remaining games this season, In addition, I don't see there is another team that might be a strong opponent for Manchester City in the remaining of their matches this season.
I have a feeling all three will play against Arsenal. Man City have a history of players pulling out of internationals, to then miraculously recover for their club shortly after.
The recent update says that Ederson and Walker are unlikely to play against Arsenal soon, but De Bruyne and Grealish have been actively participating in the training session again. Walker's condition is still bad, and I'm not expecting him to join the main squad against Arsenal as there is no ETA about when Walker will be able to recover from his injury.
I think that's not a serious problem to miss ederson since ortega is still performing quite well atm. The only problem is that the missing walker is probably weakening their right back.
Arsenal are doing the same though, Saka pulled out of England camp and Gabriel is supposedly not fit to play for Brazil. Let’s see if they are all really injured at the weekend.
The return dates for all of those players in the main squad are still unknown, and it remains uncertain when they will be back to play. Saka is now doing small treatmet for his minor injury and he can play back against manchester city.
Gabriel and Martineli's return to play remains unknown, but it would be even more interesting if both of these talented players were able to make a comeback for their respective clubs.